- Mr. Hoober-Bloob looks like Doorman of Solla Sollew
- Bub portraying the vignettes is a likely inspiration for Ted Wiggins
- The Town of Gasear is from Did I Ever Tell You How Lucky You Are?
- There's a Suprising Bug from If I Ran The Zoo
- There are two Obsks and some Bippo-No-Bungus
- There's a Bird from If I Ran The Zoo
- There's a Small Yuzz-a-Ma-Tuzz
- There are Chugs
- In the next there a Tizzle-Top Tufted Mazoorka and an Elephant-Cat
- There's a Stroodel
- There's Tweetle Bweetles
- Voice Characterizations by: Bob Holt
- Directed by: Alan Zaslove
- Produced by: Friz Freleng and Ted Geisel
- Executive Producer: David H. DePatie
- Animation: Bob Richardson, Don Williams, Norm McCabe, Warren Batchelder, Nelson Shin, Bob Matz, Bob BeMiller, Brenda Banks, Bob Bransford, Ruth Kissane, John Freeman
- Additional Voices: Hal Smith
- Backgrounds: Richard H. Thomas, Gloria Wood
- Layout: Dick Ung
- Sequence Director: Gerry Chiniquy
- In Charge of Production: Lee Gunther
- Camera: John Burton, Jr., Hogan-Lee Images
- Film Editing: Rick Steward
- Music by: Dean Elliott
- Teleplay & Lyrics by: Dr. Seuss
- Production Design by: Roy Morita
- Storyboard by: Rosemary O'Connor, Chris Jenkyns
- This the first DFE Dr. Seuss special not to have been based on any of Geisel's books.
- This is the last Dr. Seuss special to be aired on CBS.
- This is the last special to be produced by Cat in the Hat Productions and to feature the short version of the 1971-1975 Cat in the Hat Productions logo.
- This version is less of a traditional version of a Dr. Seuss story. In almost all scenes, the characters do not have horseshoe-shaped eye pupils. The color, layouts, and backgrounds are more elaborate and abstract compared to The Cat In The Hat, The Lorax and Dr. Seuss on the Loose, all of which literally resemble a fully colored, fully animated Dr. Seuss book. The specials that followed The Hoober-Bloob Highway used the same production design as The Hoober-Bloob Highway, but returned to using traditional horseshoe-shaped pupils for the characters.
- There is a major change in production staff after this special. The last of Chuck Jones's production staff (from MGM Animation/Visual Arts) such as Dean Elliott and Maurice Noble did not work on any more Dr. Seuss stories.
- This is also the last Dr. Seuss special to feature music from Dean Elliott. He was replaced by Joe Raposo.
The Hoober-Bloob Highway was nominated for a Primetime Emmy, but it lost out to Yes, Virginia, There Is a Santa Claus. Today, it is one of the lesser-known Dr. Seuss animated specials, having not been a book adaptation. It was given limited release on VHS, and can also be found alongside the VHS release of The Cat in the Hat and the VHS and DVD releases of The Grinch Grinches the Cat in the Hat. It is to be included as a bonus special on the upcoming Blu-ray release of The Cat in the Hat.
once upon a time there was a man called hoober bloob. one day on earth but somebody said, "I'm of course". said Mr. Hoober Bloob, she said on the earth, you seen the tweetle beetle battle.
boy into the fun.
and I live down the earth,
and his friend guitar.
and he lives happily ever after.
The Hoober-Bloob Highway features a number of songs, centered around the decisions the newborn must make about his future life. All the lyrics are written by Dr. Seuss, all music by Dean Elliott.
- The Hoober-Bloob Highway
- ...And That's the Way It Is, Bub
- West Watch-A-Ka-Tella
- This Is Your Life
- Among the Daisies
- That's Just the Beginning
- Things You Have to Know
- I Know the Way You Feel, Bub
- On the Other Hand, Though
- It's Fun to be a Human
- What Do You Do?
- Answer Yes or No
- You're a Human
The soundtrack was referenced by rapper Danny! through a track titled "This Is Your Life (In West Watch-A-Ka-Tella) (instrumental)" off of his album Where Is Danny? The Japanese version of this record, released via Interscope Records, replaces the aforementioned track with another instrumental titled "...And That's the Way It Is, Bub", also in reference to the soundtrack.